Tardive Dyskinesia and Dopamine Oxidation, Cumulative Effects

Abstract It is likely that tardive dyskinsesia is caused by the oxidation of dopamine in dopaminergic neurons. This oxidation produces oxygen radicals that damage neurons. Damage accumulates until tardive dyskinesia occurs. The use of dopamine D2 receptor inhibitors should be limited to the lowest doses for the shortest duration possible. View Full-Tex