Modeling Pancreatic Cancer through Somatic Editing with AAV

Genetically engineered mouse models have revolutionized the study of pancreatic cancer, but have several technical and practical limitations. A new adeno-associated virus (AAV)-driven somatic genome-editing model of pancreatic ductal adenocarcinoma reported by Ideno et al. ( Lab. Invest. published online February 6, 2019; https://doi.org/10.1038/s41374-018-0171-z) addresses several of these limitations, achieving rapid and penetrant induction of multiple targeted alterations in the adult murine pancreas