Host Genetics, Diet, and Microbiome: The Role of AMY1

Host gene variants selected by diet adaptation have been associated with the microbiome. Poole et al. ( Cell Host Microbe 2019;25;553–564.E7) reported that AMY1 copy number, associated with obesity, also impacts microbiome composition and function. Complex genetics–diet–microbiome interactions and their effect on obesity could eventually translate into personalized nutrition