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-  2019 

Mapping the Global Chromatin Connectivity Network for Sox2 Function in Neural Stem Cell Maintenance

DOI: https://doi.org/10.1016/j.stem.2019.02.004

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Abstract:

? Sox2-bound enhancers are enriched within long-range interactions in neural stem cells ? SOX2 loss decreases chromatin interactivity genome-wide ? Sox2-bound enhancers from interactions activate reporter genes in zebrafish forebrain ? Socs3, a gene downregulated in Sox2 mutant NSCs, rescues their self-renewa

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