Multi-Dimensional Roles of Ketone Bodies in Fuel Metabolism, Signaling, and Therapeutics

We leverage recent advances in stable isotope tracer based NMR and mass spectrometry-based untargeted metabolomics technologies to study metabolism on a systems level, with computational analyses of high resolution mass spectrometry datasets steadily increasing in importance. Many of these analyses proceed through provocations of ketone metabolism in genetically manipulated mouse models. Complex in vivo phenotyping methodologies are strategically aligned with these sophisticated chemical profiling platforms to generate high resolution phenotypic pictures, focusing on obesity, diabetes, NAFLD/NASH, and heart failure/CHF