Multidimensional Single-Cell Analyses in Organ Development and Maintenance

Single-cell epigenome and transcriptome analyses profile high-resolution cell atlases in organ development and maintenance. The combinatorial application of large-scale lineage tracing and single-cell transcriptomics simultaneously reveals the genetic and cell state relationship, and can help reveal the native differentiation process. Spatial transcriptomics and transcriptome-scale RNA imaging reveal the effects of spatial organization on phenotypes and functions of cells. Single-cell transcriptomics systematically reveals the cell–cell interaction networks within an organ or in different organs