Sensing Mitochondrial Acetyl-CoA to Tune Respiration

Fatty acid synthesis (FAS) in mitochondria produces a key metabolite called lipoic acid. However, a new study by Van Vranken et al. [ 1 Van Vranken J.G. et al. ACP acylation is an acetyl-CoA-dependent modification required for electron transport chain assembly. Mol. Cell. 2018; 71 : 567-580 Abstract Full Text Full Text PDF PubMed Scopus (0) Google Scholar ] ( Mol. Cell 2018;71:567–580) shows that mitochondrial FAS regulates the assembly of oxidative phosphorylation complexes, thereby functioning as a nutrient sensor for mitochondrial respiration