Nckipsd Coordinates Arp2/3 and Formin Nucleation of Actin Filaments in the Cell Cortex

Modulating the organisation of the cell cortex is essential during the cell cycle and for cell migration. The cortical actin network can be regulated through the control of actin nucleation. There are two main actin nucleators in the cortex: the Arp2/3 complex, which generates branched filaments off the sides of existing filaments; and formin mDia1, which can nucleate and rapidly elongate filaments. However, how these two nucleators are coordinated is still unclear