A “Connexin” Responsible for the Fatal Attraction of Cancer to Bone

Tumor cell interactions with the bone microenvironment are vital for the establishment and progression of bone metastases. Recently in Cancer Cell, Wang et al. (2018) Wang H. Tian L. Liu J. Goldstein A. Bado I. Zhang W. Arenkiel B.R. Li Z. Yang M. Du S. et al. The osteogenic niche is a calcium reservoir of bone micrometastases and confers unexpected therapeutic vulnerability. Cancer Cell. 2018; 34 : 823-839.e7 Abstract Full Text Full Text PDF PubMed Scopus (2) Google Scholar showed that cells of the osteoblast lineage are critical for the delivery of calcium to tumor cells through gap junctions, pointing toward potential therapies for bone metastases