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- 2019
Deubiquitinases Maintain Protein Homeostasis and Survival of Cancer Cells upon Glutathione DepletionDOI: https://doi.org/10.1016/j.cmet.2019.01.020 Abstract: ？ Most cancer cell lines are largely insensitive to GSH depletion ？ Deubiquitinases (DUBs) protect cancer cells upon inhibition of GSH synthesis ？ Inhibition of DUBs and GSH synthesis causes ER and proteotoxic stress and cell death ？ Combined targeting of DUBs and GSH blocks tumor growt
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