RIPK3: Beyond Necroptosis

In this issue of Immunity, Daniels et al. (2019) Daniels B.P. Kofman S.B. Smith J.R. Norris G.T. Snyder A.G. Kolb J.P. Gao X. Locasale J.W. Martinez J. Gale Jr., M.G. et al. The Nucleotide Sensor ZBP1 and Kinase RIPK3 Induce the Enzyme IRG1 to Promote an Antiviral Metabolic State in Neurons. Immunity. 2019; 50 ( this issue) : 64-76 Abstract Full Text Full Text PDF Google Scholar demonstrate that RIPK3 signaling limits Zika virus (ZIKV) infection in the central nervous system independently of its function in necroptosis by promoting itaconate production in infected neurons, thereby revealing a neuron-specific mechanism of metabolite-mediated ZIKV control