Testing Models of Human Declarative Memory at the Single-Neuron Level

Single-neuron recordings in humans are a powerful technique to bridge theory and experimentation in cognitive neuroscience Recordings of novelty-sensitive dopamine neurons confirm critical predictions of the VTA/SN–hippocampus loop model Visually and memory-selective cells in the human MTL form a sparse and highly abstract code that are a putative candidate for semantic and episodic memories, respectively. Neurons in PPC are candidates for mnemonic evidence accumulators. Contextual reinstatement during retrieval and slowly drifting neural state during encoding confirm key prediction of temporal context models of episodic memory