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-  2019 

ROS and Oxidative Stress Are Elevated in Mitosis during Asynchronous Cell Cycle Progression and Are Exacerbated by Mitotic Arrest

DOI: https://doi.org/10.1016/j.cels.2019.01.005

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Abstract:

? ROS varies with the cell cycle in freely cycling cancer cells ? ROS levels peak in G2 and mitosis ? Oxidation of biomolecules is maximal in mitosis ? Mitotic arrest further enhances ROS and oxidative damage to proteins and nucleotide

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