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-  2019 

Convergent Identification and Interrogation of Tumor-Intrinsic Factors that Modulate Cancer Immunity In Vivo

DOI: https://doi.org/10.1016/j.cels.2019.01.004

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Abstract:

? Genome-scale in vivo CRISPR screens identified tumor-intrinsic factors of oncogenesis ? Prkar1a is a strong genetic driver of oncogenesis ? Prkar1a loss altered the transcriptome and proteome in immune responses ? Prkar1a mutation in cancer cells remodels the tumor microenvironmen

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