Effector Specificity Mechanisms of Rab35 GTPase

The mechanism of GTPase specificity remains incompletely understood. In this issue of Structure, Lin et al. (2019) Lin L. Shi Y. Wang M. Wang C. Zhu J. Zhang R. Rab35/ACAP2 and Rab35/RUSC2 Complex Structures Reveal Molecular Basis for Effector Recognition by Rab35 GTPase. Structure. 2019; 27 ( this issue) : 729-740 Google Scholar present crystal structures of Rab35 in complex with two effectors, ACAP2 and RUSC2, respectively, unraveling the molecular basis for the exquisite mutual specificity between Rab35 and these effectors