A Dual Role for TNF-Producing T Cells in the Fetal Intestine

The role of tumor necrosis factor (TNF) in the fetal intestine is poorly understood. In this issue of Immunity, Schreurs et al. (2019) Schreurs R.R.C.E. Martin E.B. Sagebiel A.F. Kaufmann M. Mokry M. Klarenbeek P.L. Schaltenberg N. Steinert F.L. van Rijn J.M. Drewniak A. et al. Human fetal TNF-α-cytokine-producing CD4 + effector memory T cells promote intestinal development and mediate inflammation early in life. Immunity. 2019; 50 ( this issue) : 462-476 Abstract Full Text Full Text PDF PubMed Scopus (1) Google Scholar identify important roles of TNF-producing T cells as both regulators of gut development and potential inducers of colitis