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-  2019 

Specific Decrease in B-Cell-Derived Extracellular Vesicles Enhances Post-Chemotherapeutic CD8+ T Cell Responses

DOI: https://doi.org/10.1016/j.immuni.2019.01.010

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Abstract:

? CD19 + EVs through CD39 and CD73 hydrolyze ATP from tumor cells into adenosine ? CD19 + EVs blunt post-chemotherapeutic CD8 T cell responses via adenosine ? Tumor B cells produce more EVs by enhancing HIF-1α-mediated Rab27a transcription ? IEBVs- Rab27a siRNA is a potential tool for improving chemotherapeutic effec

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