Breaking Symmetry: Worm Cue Finally Found

In this issue of Developmental Cell, Zhao et al. (2019) Zhao P. Teng X. Tantirimudalige S.N. Nishikawa M. Wohland T. Toyama Y. Motegi F. Aurora-A breaks symmetry in contractile actomyosin networks independently of its role in centrosome maturation. Dev. Cell. 2019; 48 ( this issue) : 631-645 Abstract Full Text Full Text PDF Scopus (1) Google Scholar show that the Aurora A kinase AIR-1 is the long-sought cue that downregulates cortical actomyosin to establish anterior-posterior polarity in the C. elegans zygote, diffusing from centrosomes to the overlying cortex to phosphorylate yet to be identified target(s)