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-  2019 

A Simple and Flexible Computational Framework for Inferring Sources of Heterogeneity from Single-Cell Dynamics

DOI: https://doi.org/10.1016/j.cels.2018.12.007

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Abstract:

? Dynamic single-cell data pose opportunities and challenges for mechanistic models ? Non-linear mixed-effects models disentangle sources of cellular heterogeneity ? Methods for flexible, scalable parameter inference and for sub-process identification ? Several sub-processes contribute dynamically to heterogeneity in yeast endocytosi

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