A De Novo Shape Motif Discovery Algorithm Reveals Preferences of Transcription Factors for DNA Shape Beyond Sequence Motifs

？ The ShapeMF algorithm works on DNA shape data, extending de novo motif discovery ？ ShapeMF identifies shape motifs enriched in regions bound by transcription factors ？ Many transcription factors have shape motifs in both in vivo and in vitro data ？ Shape motifs may encode specificity that goes beyond the sequence motifs of a T