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-  2019 

Advancing Chemokine GPCR Structure Based Drug Discovery

DOI: https://doi.org/10.1016/j.str.2019.02.004

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Abstract:

In this issue of Structure, Apel et al., (2019) Apel A.K. Cheng R.K.Y. Tautermann C.S. Brauchle M. Huang C.Y. Pautsch A. Hennig M. Nar H. Schnapp G. Crystal structure of CC chemokine receptor 2A in complex with an orthosteric antagonist provides insights for the design of selective antagonists. Structure. 2019; 27 ( this issue) : 427-438 Google Scholar provide structural insight into the inhibition of a human chemokine G-protein-coupled receptor by a small-molecule antagonist, which advances our understanding of drug design principles for this complex family of receptors

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