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-  2019 

A Regulatory Circuit Controlling the Dynamics of NFκB cRel Transitions B Cells from Proliferation to Plasma Cell Differentiation

DOI: https://doi.org/10.1016/j.immuni.2019.02.004

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Abstract:

? cRel drives B cell proliferation but blocks antibody-secreting cell differentiation ? In ASCs, RelA-induced Blimp1 represses cRel via binding the Rel enhancer ? NFκB dynamics transition cells across the bi-stable ABC-ASC differentiation network ? Multi-scale model of single-cell-fate decisions explains B cell population dynamic

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