Recasting the Tissue-Resident Lymphocyte in Celiac Disease

In a recent issue of Cell, Mayassi et al. (2019) Mayassi T. Ladell K. Gudjonson H. McLaren J.E. Shaw D.G. Tran M.T. Rokicka J.J. Lawrence I. Grenier J.C. van Unen V. et al. Chronic Inflammation Permanently Reshapes Tissue-Resident Immunity in Celiac Disease. Cell. 2019; 176 : 967-981 Abstract Full Text Full Text PDF PubMed Scopus (1) Google Scholar show that chronic inflammation in celiac disease (CeD) patients changes the repertoire and functional phenotype of intestinal TCR γδ + intraepithelial lymphocytes. These changes are not reversed by gluten-free dietary regimens, suggesting that they might underlie the long-term sensitivity of CeD patients to gluten