Exosomes Exercise Inhibition of Anti-Tumor Immunity during Chemotherapy

Exosomes are nano-sized extracellular vesicles that contain DNA, RNA, proteins, and lipids. Exosomes likely participate in facilitating intercellular communication and tumor growth. In this issue of Immunity, Zhang et al. (2019) Zhang F. Li R. Yang Y. Shi C. Shen Y. Lu C. Chen Y. Zhou W. Lin A. Yu L. et al. Specific Decrease in B-Cell-Derived Extracellular Vesicles Enhances Post-Chemotherapeutic CD8 + T Cell Responses. Immunity. 2019; 50 ( this issue) : 738-750 Google Scholar report on the metabolic activity of B cell-derived exosomes in facilitating the suppression of cytotoxic T cells