Sugar Fix Keeps RIPK3 at Bay

Immunometabolism is emerging as an important modulator of immune responses. In this issue of Immunity, Li et al. (2019) Li X. Gong W. Wang H. Li T. Attri K.S. Lewis R.E. Kalil A.C. Bhinderwala F. Powers R. Yin G. et al. O-GlcNAc transferase suppresses inflammation and necroptosis by targeting receptor-interacting serine/threonine-protein kinase 3. Immunity. 2019; 50 ( this issue) : 576-590 Google Scholar examine the link between lipopolysaccharide (LPS)-induced glucose metabolism and innate immune signaling and identify how β-N-acetylglucosamine ( O-GlcNAc) modification of the RIPK3 RHIM domain limits inflammation and necroptosis