Prometheus Unbound in Ya(p) Heart

The adult mammalian heart, unlike in some amphibian and fish species, is generally considered a post-mitotic organ. In this issue of Developmental Cell, Monroe et al. (2019) Monroe T.O. Hill M.C. Morikawa Y. Leach J.P. Heallen T. Cao S. Krijger P.H.L. de Laat W. Wehrens X.H.T. Rodney G.G. Martin J.F. YAP partially reprograms chromatin accessibility to directly induce adult cardiogenesis in vivo. Dev. Cell. 2019; 48 ( this issue) : 765-779 Google Scholar show that the expression of constitutively active YAP induces a remarkable degree of proliferation in preexisting adult cardiomyocytes by globally altering chromatin accessibility