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-  2019 

ROS Inhibits Cell Growth by Regulating 4EBP and S6K, Independent of TOR, during Development

DOI: https://doi.org/10.1016/j.devcel.2019.04.008

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Abstract:

? High level of cellular ROS restricts cell growth by regulating 4EBP and S6K expression ? The regulation of 4EBP and S6K is independent of the insulin signaling cascade ? Prior to pupation, ecdysone triggers this pathway by raising the ROS level ? This pathway antagonizes insulin signaling to determine organismal siz

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