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-  2019 

Enhanced Dendritic Actin Network Formation in Extended Lamellipodia Drives Proliferation in Growth-Challenged Rac1P29S Melanoma Cells

DOI: https://doi.org/10.1016/j.devcel.2019.04.007

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Abstract:

? Rac1 P29S confers proliferative advantage during melanoma metastasis and drug treatment ? Rac1 P29S sustains proliferation in drug-challenged cells by elongation of lamellipodia ? Rac1 P29S-driven proliferation needs matrix attachment but not focal adhesion signaling ? Elongated lamellipodia in Rac1 P29S cells sequester and phospho-inactivate NF2/Merli

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