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-  2019 

T-bet Transcription Factor Promotes Antibody-Secreting Cell Differentiation by Limiting the Inflammatory Effects of IFN-γ on B Cells

DOI: https://doi.org/10.1016/j.immuni.2019.04.004

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Abstract:

? Differentiation of Th1-activated B (Be1) cells requires B intrinsic T-bet and IFN-γR ? Be1 differentiation requires T-bet repression of NF-κB, TLR, and STAT pathways ? Plasma cell formation in Be2 cultures and nematode infection is T-bet independent ? T-bet controls formation of long-lived and secondary plasma cells in flu infectio

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