The Timed Pathway to Homeostasis

Al Nabhani et al. (2019) Al Nabhani Z. Dulauroy S. Marques R. Cousu C. Al Bounny S. Déjardin F. Sparwasser T. Bérard M. Cerf-Bensussan N. Eberl G. A weaning reaction to microbiota Is required for resistance to immunopathologies in the adult. Immunity. 2019; 50 ( this issue) : 1276-1288 Google Scholar describe the weaning reaction, a transient, microbiota-induced innate immune stimulation during the third and fourth weeks after birth that is associated with protection from immune-mediated enteric diseases in adulthood. This strictly timed, non-redundant process highlights the cooperative action of dietary, microbial, and developmental factors in the establishment of immune homeostasis