Sorting Out Fate Determination

How organ morphogenesis specifies cell fate and whether organ progenitors are predetermined or specified via niche signals are critical developmental biology questions. In this issue of Developmental Cell, Nyeng et al. (2019) Nyeng P. Heilmann S. L？f-？hlin Z.M. Pettersson N.F. Hermann F.M. Reynolds A.B. Semb H. p120ctn-mediated organ patterning precedes and determines pancreatic progenitor fate. Dev. Cell. 2019; 49 ( this issue) : 31-47 Google Scholar modulate cell-cell adhesion in the pancreas and provide evidence that progenitors are plastic and instructed by niche signals