Mast Cells Get on Your Nerves in Itch

Mast-cell-nerve interactions play an integral role in itch and inflammation. Meixiong et al. (2019) Meixiong J. Anderson M. Limjunyawong N. Sabbagh F.M. Hu E. Mack M.R. Oetjen L.K. Wang F. Kim B.S. Dong X. Activation of mast cell-expressed Mas-related G-1 protein coupled receptors drives non histaminergic itch. Immunity. 2019; 50 ( this issue) : 1163-1171 Google Scholar show that the receptors MRGPRB2 and FcεRI mediate distinct types of mast cell activation and nerve interactions and that mast cell activation through MRGPRB2 drives itch in allergic contact dermatitis