Mechano-regulation of Peptide-MHC Class I Conformations Determines TCR Antigen Recognition

？ Force-enhanced peptide-TCR interactions determine TCR-pMHC-I catch bonds ？ Force-strengthened TCR-MHC binding interface contributes to TCR-pMHC-I catch bonds ？ Force-induced MHC-I rotation allosterically enhances TCR-pMHC-I catch bonds ？ Tumor-associated somatic mutations in HLA-A2 impair TCR-pHLA-A2 catch bond