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-  2019 

LC Domain-Mediated Coalescence Is Essential for Otu Enzymatic Activity to Extend Drosophila Lifespan

DOI: https://doi.org/10.1016/j.molcel.2019.02.004

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Abstract:

? LC domain-mediated coalescence is essential for Otu deubiquitinase activity ? RNAs bind LC domain and enhance Otu coalescence and its enzyme activity ? Otu/Bam complex targets dTraf6 to maintain gut immune homeostasis ? Dynamic regulation of Otu/Bam granules in guts controls fly lifespa

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