Competition for Food Drives Stem Cell Fate in Facultative Niches

Mechanisms regulating maintenance of the stem cell pool in facultative niches of the mammalian testis are poorly understood. In this issue of Cell Stem Cell, Kitadate et al. (2019) Kitadate Y. J？rg D.J. Yokue M. Maruyama A. Ichikawa R. Tsuchiya S. Segi-Nishida E. Nakagawa T. Uchida A. Kimura-Yoshida C. et al. Competition for mitogens regulates spermatogenic stem cell homeostasis in an open niche. Cell Stem Cell. 2019; 24 ( this issue) : 79-92 Abstract Full Text Full Text PDF PubMed Scopus (1) Google Scholar propose a minimal model in which stem cells compete for limited resources of fibroblast growth factors, which predicts their density during homeostasis and regenerative conditions