Demystifying Microglia: And Now the Work Begins

Microglia actively shape the developing brain, but their transcriptional diversity is not well understood. Complementary studies by Hammond et al. (2018) Hammond T.R. Dufort C. Dissing-Olesen L. Giera S. Young A. Wysoker A. Walker A.J. Gergits F. Segel M. Nemesh J. et al. Single-Cell RNA Sequencing of Microglia throughout the Mouse Lifespan and in the Injured Brain Reveals Complex Cell-State Changes. Immunity. 2018; 50 ( this issue) : 253-271 Abstract Full Text Full Text PDF PubMed Scopus (1) Google Scholar and Li et al. (2019) Li Q. Cheng Z. Zhou L. Darmanis S. Neff N.F. Okamoto J. Gulati G. Bennett M.L. Sun L.O. Clarke L.E. et al. Developmental heterogeneity of microglia and brain myeloid cells revealed by deep single-cell RNA sequencing. Neuron. 2019; 101 10.1016/j.neuron.2018.12.006 Abstract Full Text Full Text PDF Google Scholar characterize the microglial transcriptome at single cell resolution, highlighting their diversity during development, aging, and pathology