NIPSNAP Beacons in Mitophagy

In healthy cells, dysfunctional mitochondria are removed by selective autophagy (mitophagy), impairment of which causes disease. In this issue of Developmental Cell, Princely Abudu et al. (2019) Princely Abudu Y. Pankiv S. Mathai B.J. H？kon Lystad A. Bindesb？ll C. Brenne H.B. Yoke Wui Ng M. Thiede B. Yamamoto A. Mutugi Nthiga T. et al. NIPSNAP1 and NIPSNAP2 act as “eat me” signals for mitophagy. Dev. Cell. 2019; 49 ( this issue) : 509-525 Google Scholar delineate the function of NIPSNAP1 and NIPSNAP2 in recruiting mitophagy receptors to depolarized mitochondria, highlighting their importance in the zebrafish brain