Dual Role of Ribosome-Binding Domain of NAC as a Potent Suppressor of Protein Aggregation and Aging-Related Proteinopathies

？ The protein biogenesis factor NAC exhibits broad-spectrum chaperone activity ？ NAC exerts a ribosome-independent chaperone function ？ The positively charged N terminus of βNAC is a central chaperone entity of NAC ？ NAC suppresses aggregation and toxicity of disease-related polyglutamine protein