The Landscape of L1 Retrotransposons in the Human Genome Is Shaped by Pre-insertion Sequence Biases and Post-insertion Selection

？ High-throughput insertion site profiling of a LINE-1 (L1) element by ATLAS-seq ？ Insertion is influenced strongly by DNA sequence but only weakly by chromatin state ？ L1 integration preferences suggest a link with host DNA replication ？ Post-insertion selection reshapes L1 distribution across functional genomic region