Close Quarters Can Be a Good Fit for Stem Cells to Become T Cells

Human pluripotent stem cells (PSCs) could potentially provide a potentially unlimited supply of T cells. In this issue of Cell Stem Cell, Montel-Hagen et al. (2019) Montel-Hagen A. Seet C.S. Li S. Chick B. Zhu Y. Chang P. Tsai S. Sun V. Lopez S. Chen H.C. et al. Organoid-induced differentiation of conventional T cells from human pluripotent stem cells. Cell Stem Cell. 2019; 24 ( this issue) : 376-389 Abstract Full Text Full Text PDF PubMed Scopus (2) Google Scholar take advantage of a three-dimensional mouse stromal cell-based system that combines mesoderm specification with organoid-induced hematopoietic differentiation to enable commitment, selection, and maturation of conventional human T cells