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-  2019 

A Diet-Sensitive Commensal Lactobacillus Strain Mediates TLR7-Dependent Systemic Autoimmunity

DOI: https://doi.org/10.1016/j.chom.2018.11.009

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Abstract:

? L. reuteri colonizes lupus-prone hosts and translocates to MLN, liver, and spleen ? L. reuteri exacerbates TLR7-dependent lupus in conventional and germ-free mice ? Resistant starch ameliorates pDCs, type I IFN pathways, and lupus-related mortality ? Starch diet-derived short-chain fatty acids suppress L. reuteri in vitro and in viv

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