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-  2019 

Continued Activity of the Pioneer Factor Zelda Is Required to Drive Zygotic Genome Activation

DOI: https://doi.org/10.1016/j.molcel.2019.01.014

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Abstract:

? An N-terminal CRY2 tag allows rapid and reversible transcription factor inactivation ? Zelda activity is required throughout zygotic genome activation in Drosophila embryos ? Zelda is a pioneer factor that binds with sequence specificity to nucleosomal DNA ? Nucleosome binding by pioneer factors may enable genome access during S phas

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