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-  2019 

Oligoadenylate-Synthetase-Family Protein OASL Inhibits Activity of the DNA Sensor cGAS during DNA Virus Infection to Limit Interferon Production

DOI: https://doi.org/10.1016/j.immuni.2018.12.013

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Abstract:

? Loss of human OASL and mouse Oasl2 inhibits DNA virus infection ? OASL and Oasl2 inhibit cGAS-mediated IFN induction ? OASL specifically binds to cGAS to inhibit cGAS enzyme activity ? OASL binds to cGAS independently of double-stranded DN

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