Defining Dysbiosis in Inflammatory Bowel Disease

In this issue of Immunity, Britton et al. (2019) Britton G.J. Contijoch E.J. Mogno I. Vennaro O.H. Llewellyn S.R. Ng R. Li Z. Mortha A. Merad M. Das A. et al. Microbiotas from humans with inflammatory bowel disease alter the balance of gut Th17 and RORγt + regulatory T cells and exacerbate colitis in mice. Immunity. 2019; 50 ( this issue) : 212-224 Abstract Full Text Full Text PDF Scopus (1) Google Scholar demonstrate that the colonization of germ-free mice with microbiotas from inflammatory bowel disease patients induces an altered ratio of RORγt + regulatory T cells to T(h17) effector cells and recapitulates human disease severity in colitis-susceptible mice