Coronin-1, King of Alloimmunity

Defining pathways that differentially regulate graft-reactive versus anti-microbial T cell responses could facilitate more precise manipulation of immune responses in the context of organ and tissue transplantation. Here, Jayachandran et al. (2019) Jayachandran R. Gumienny A. Bolinger B. Ruehl S. Lang M.J. Fucile G. Mazumder S. Tchang V. Woischnig A.-K. Stiess M. et al. Disruption of Coronin 1 Signaling in T Cells Promotes Allograft Tolerance while Maintaining Anti-Pathogen Immunity. Immunity. 2019; 50 ( this issue) : 152-165 Abstract Full Text Full Text PDF Google Scholar identify a coronin-1-PDE4-cAMP axis that, when perturbed, results in the induction of transplantation tolerance while maintaining anti-microbial immunity