Histone Serotonylation: Can the Brain Have “Happy” Chromatin?

Recent work from Farrelly et al. (2019) Farrelly L.A. Thompson R.E. Zhao S. Lepack A.E. Lyu Y. Bhanu N.V. Zhang B. Loh Y.-H.E. Ramakrishnan A. Vadodaria K.C. et al. Histone serotonylation is a permissive modification that enhances TFIID binding to H3K4me. Nature. 2019; 567 : 535-539 Crossref PubMed Scopus (2) Google Scholar indicates that histone tails can be serotonylated, suggesting a previously unappreciated direct mechanism of potential crosstalk between bioactive amines and the epigenome