Deterministic Somatic Cell Reprogramming Involves Continuous Transcriptional Changes Governed by Myc and Epigenetic-Driven Modules

？ Unbiased high-resolution profiling of mouse deterministic reprogramming to naive iPSCs ？ Early DNA demethylation of pluripotency enhancers definitively marks future iPSCs ？ Myc activity is indispensable for conducive iPS formation from somatic cells ？ Optimized changes in tRNA codon usage amplify the output of Myc governed progra