Fiber Puts Lactobacillus to SLEep

Few studies have analyzed how diet-induced changes in the microbiota influence lupus. In this issue of Cell Host & Microbe, Zegarra-Ruiz et al. (2019) Zegarra-Ruiz D.F. El Beidaq A. I？iguez A.J. Di Ricco M.L. Vieira S.M. Ruff W.E. Mubiru D. Fine R.L. Sterpka J. Greiling T.M. et al. A diet-sensitive commensal Lactobacillus strain mediates TLR7-dependent systemic autoimmunity. Cell Host Microbe. 2019; 25 ( this issue) : 113-127 Google Scholar find that translocation of Lactobacillus reuteri from the gut to systemic organs worsens lupus. However, diets with resistant starch restrict L. reuteri growth and ameliorate disease