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-  2019 

NLRP12 Regulates Anti-viral RIG-I Activation via Interaction with TRIM25

DOI: https://doi.org/10.1016/j.chom.2019.02.013

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Abstract:

? NLRP12 reduces interferon and cytokine responses to RNA viruses and 5′ppp-dsRNA ? NLRP12 associates with TRIM25 to disrupt Lys63 ubiquitination and activation of RIG-I ? Vesicular stomatitis virus (VSV) infection downregulates NLRP12 ? Myeloid-specific Nlrp12-deficient mice have increased resistance to VS

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