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-  2019 

Drosophila Histone Demethylase KDM5 Regulates Social Behavior through Immune Control and Gut Microbiota Maintenance

DOI: https://doi.org/10.1016/j.chom.2019.02.003

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Abstract:

? Deficiency of KDM5 demethylase causes gut dysbiosis and abnormal social behavior in flies ? Lactobacillus plantarum administration improves social behavior in kdm5-deficient animals ? KDM5 maintains proper immune activity in a transcriptional and microbiota-mediated manner ? KDM5 demethylase affects social behavior through the gut-microbiome-brain axi

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